Aggressive-Behavior Predictors in Solitary Fibrous Tumor

Description

The presented study focuses on the aggressive behavior and metastasis of solitary fibrous tumors (SFTs), which have been historically considered to exhibit uncertain characteristics. The research analyzes data from 81 patients treated at McGill University Health Center between 1984 and 2017, involving surgical dissection of tumors and an average follow-up of 59 months. The study identifies various histopathological diagnoses, including different types of SFTs and suggests classification based on histology. Key findings reveal significant correlations between tumor size, histopathological type, local recurrence, and metastasis, particularly noting that cellular SFT forms and large tumor diameters are associated with worse outcomes. Additionally, the study indicates that positive surgical margins led to an increase in local recurrence rates, while age, gender, and certain mitotic factors showed no clear association with metastasis or survival outcomes. Overall, the study emphasizes the importance of maintaining negative margins and suggests applying grading systems based on tumor cellularity to better predict aggressive behaviors in SFTs.

DOI: 10.1302/3114-210027

Specialties