Engineered Functional Cartilage Models in Repair and Disease Modelling

Description

The transcription appears to be from a scientific presentation focusing on engineered functional cartilage models, specifically detailing the research and findings of Professor Adetola Adesida from the McCaig Institute in Edmonton, Canada. The presentation begins with introductions, where Professor Adesida expresses gratitude for the opportunity to speak and begins to share insights on cartilage repair and disease modeling. He discusses topics such as the limitations of current cartilage repair methods, the use of bone marrow-derived mesenchymal stem cells for cartilage regeneration, and the challenges related to the differentiation of these cells during culture.



He outlines various experimental designs, including studies involving sheep models and the effect of hypoxic conditions on cartilage repair. The goal is to understand the efficacy of engineered cartilage in replicating natural tissue and improving healing outcomes. Professor Adesida highlights the significance of environmental factors such as oxygen tension on cell behavior, the development of engineered cartilage, and the challenges presented by the inherent variability in human tissue samples.



Moreover, he addresses the methodological advancements in using TGF-beta to enhance cellular responses and the promising results obtained from mechanical loading to improve tissue functionality. The presentation also delves into meniscus tissue, emphasizing its under-researched status compared to articular cartilage and the biomaterial innovations being explored in the context of osteoarthritis, especially considering gender-based physiological differences. Throughout the talk, Professor Adesida conveys a sense of optimism for the future of cartilage engineering and its potential clinical applications, while also acknowledging the need for further research to refine techniques and enhance therapeutic outcomes.

DOI: 10.1302/3114-221103

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