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- Talk
- UK
The Role of Joint Shape in Osteoarthritis Onset and Progression
Description
In this presentation, Richard Aspden discusses the intricate relationship between joint shape and the pathogenesis of osteoarthritis (OA). Despite extensive research, the understanding of this relationship remains limited. Aspden presents innovative methods developed for quantifying joint shape, aimed at serving as imaging biomarkers for OA progression. He emphasizes the significance of joint morphology, citing conditions like acetabular dysplasia and femoroacetabular impingement as key factors that increase OA risk.
The presentation outlines the evolution of geometrical measures of joint morphology and highlights the limitations faced, such as accuracy and precision in measuring angles and dimensions. Aspden introduces a novel approach using Statistical Shape Models (SSM) derived from various imaging modalities to analyze hip morphology more reliably and quantitatively. He explains how this method enables researchers to identify complex relationships in joint shape variations.
Aspden showcases data from two pivotal studies, the Rotterdam Study and a primary care rheumatology study, which utilized SSMs to discover correlations between hip morphology and OA progression. The findings demonstrate that baseline shape variations can be indicative of future OA development, particularly in individuals requiring total hip replacements.
Furthermore, he discusses other studies involving body mass index, age-related changes, and genetic influences on joint morphology. The innovative approaches outlined in this presentation open new avenues for understanding OA, offering improved accuracy and sensitivity over traditional measurement techniques. Aspden concludes by thanking collaborators and funding bodies for their support in this research journey.