Prediction Models for Survival, Local Recurrence and Metastases of Leiomyosarcomas of Trunk Wall and Extremities: A Multicentre Study

Description

In this presentation, Sudhir Kannan introduces a multicenter study focused on predicting mortality, local recurrence, and metastases in leiomyosarcomas located in the trunk wall and extremities. He highlights the high mortality rates and metastasis associated with soft tissue sarcomas, particularly leiomyosarcomas, which account for roughly 10% of these rare tumors. The study aims to quantify various clinical and pathological factors affecting these tumors using data collected from multiple centers within and outside the UK.



Kannan discusses the demographics of the cohort, noting a mean age of 70 years with a significant male majority (61%). The majority of tumors were high-grade and large in size, often found deep within the fascia. Histopathological evaluations indicated a common presence of necrosis and vascular invasion.



He outlines treatment data, revealing that a quarter of patients received chemoradiotherapy, and summarizes critical findings: a median survival of 38.2 months, a local recurrence rate of 14%, and a metastasis rate of 58%. The presentation emphasizes the association of larger tumor size, high-grade classification, and necrosis with poor survival outcomes.



Kannan elaborates on the development of three prediction models, or nomograms, designed to assess mortality, recurrence, and metastasis risk. These models, which leverage individual patient characteristics to calculate risks, showed predictive accuracy ranging from 80% to 88%. He concludes with the hope of validating these findings through ongoing research and acknowledges that the data from additional centers is still being analyzed.

DOI: 10.1302/3114-221487

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