Basic Sciences - Structure of Proteoglycan

Description

This transcript explores the detailed structure of the proteoglycan aggrecan, pivotal for the osmotic properties of cartilage, which enables it to withstand compressive forces. Initially, the presentation provides an overview of proteoglycans, highlighting the covalent attachment of glycosaminoglycans to core proteins, with aggrecan being a significant example. It describes two distinct chondroitin sulfate regions, S1 and S2, characterized by their unique spacing patterns of achondrite and sulfate chains. Additionally, it mentions the non-covalent binding of proteoglycan to hyaluronic acid through a linking protein. The structural makeup is further elaborated upon with references to the globular folded regions G1, G2, and G3 of the core protein, all of which contribute to the functioning of cartilage. The presentation concludes with a call to action encouraging viewers to subscribe and like the content.

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