The Effect of Repeated Mechanical Loading on Bone Adaptation in a Mouse Model of Oestrogen Deficiency

Description

In this presentation by Vee San Cheong, the focus is on the critical understanding of how mechanical loading influences bone adaptation, specifically in the context of managing bone diseases. The talk outlines an experimental study assessing the effects of mechanical loading on ovariectomized (OVX) mouse tibia over a longitudinal period. Key methodologies include the application of mechanical loads through multiple sessions and the use of a SCANCO micro-CT scanner for imaging. Results reveal significant findings: mechanical loading increased bone apposition and reduced resorption following the first loading session, while subsequent applications exhibited varied responses. Overall, the study illustrates that initial mechanical loading has a pronounced impact on bone remodeling and suggests that modifying peak load and loading rates could optimize bone adaptation. Acknowledgments are given to EPSRC and NC3R for their support of this research.

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