Description
In this comprehensive presentation on osteoarthritis (OA), Mark Wilkinson addresses its prevalence, risk factors, and underlying mechanisms. He opens by thanking his colleagues and outlines the significance of OA, emphasizing that it affects around 7% of the global population, particularly those over 45 years of age. The presentation details the various etiologies of osteoarthritis, noting that it is a disease of the entire joint rather than just the cartilage, characterized by developments such as cartilage loss and the thickening of ligamentous structures.
Using slides, Wilkinson explains the importance of understanding the microscopic changes in cartilage associated with OA and the associated pain pathways. He shares epidemiological data indicating a dramatic rise in OA over recent decades, linking it to significant disability, mortality risks, and economic burdens in healthcare systems.
The conversation progresses into the genetic components of OA, highlighting the complex interactions between genetics, age, obesity, and gender risks. He notes that while aging is a primary factor, obesity significantly increases the risk due to joint loading and inflammatory cytokines produced by adipose tissue.
Wilkinson discusses the challenges in identifying effective therapies and preventive measures, as there are currently no disease-modifying treatments. He solicits further research into genetic risk factors and the identification of targets for novel interventions to help manage and prevent OA.
The session concludes with an interactive Q&A, addressing practical considerations in treatment pathways and the impact of mechanical alignment and other risk factors in OA management.