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- Talk
- 13/09/2021
- UK
Bridging Disciplines as Pathway to Finding New Solutions for Osteoarthritis (OA)
Description
This talk by Thomas Andriacchi addresses the intersection of various disciplines in orthopedic research, particularly focusing on osteoarthritis (OA). The title, "Bridging Disciplines is a Pathway to Finding New Solutions for Osteoarthritis," encapsulates the essence of the presentation, which was derived from a collaborative effort between the Orthopedic Research Society and the Osteoarthritis Society International.
Andriacchi presents findings from a meeting that generated critical discussions on unanswered questions surrounding OA. He reflects on the diversity of inquiries posed by participants, emphasizing that intedisciplinary interaction is essential in advancing research and understanding of OA. Through metaphors such as the blind men and the elephant, he illustrates the fragmented view often experienced within OA research, where various disciplines may focus on different aspects of the disease (e.g., cartilage vs. bone) without sufficient communication.
The presentation also delves into key outcomes identified at the meeting, including:
- Osteoarthritis is not a single disease but rather a complex integration of multiple factors.
- Environmental and genetic factors significantly influence the initiation and progression of OA, warranting a personalized approach to treatment.
- The variability in pain experiences among patients points to the need for research that connects psychological aspects with the biological processes in OA.
- Mechanical factors play a crucial role, where changes in gait resulting from pain or injury could impact the progression of OA.
Andriacchi promotes the concept of mechanokines, a term reflecting the intersection of mechanical signals and biological responses in OA. He asserts that understanding the interactions between gait mechanics and cellular responses can provide valuable insights into disease progression.
He advocates for a collaborative approach, urging researchers to break down 'silos' within their disciplines, allowing for richer dialogue and innovation. The conclusion emphasizes the importance of building bridges—not walls—between various fields to foster holistic solutions for osteoarthritis.