Description
The VTT outlines a detailed discussion session focused on various clinical approaches and considerations for treating patients with sarcomas, specifically osteosarcoma of the proximal humerus. Krista Goulding serves as the moderator, inviting participants to ask questions. Dr. Alexander Athey discusses treatment options for a 25-year-old patient with osteosarcoma, advocating for a reverse AP construct and expressing a preference to avoid shoulder arthrodesis when possible. The conversation shifts to technical aspects of reverse shoulder replacements, where Athey advises using off-the-shelf glenoid components unless a custom solution is necessary due to patient size. The discussion continues with questions regarding endoprosthetic replacements for patients with metastatic disease, with Athey confirming their preference for this approach in cases of pathologic fractures.
Following this, Kayla Marritt discusses her preclinical research on combining sting activation with immunotherapy, noting the potential for improved survival rates. The session also covers the challenges of transferring insights from preclinical models to clinical practice, with Marritt highlighting ongoing work in understanding the mechanism of action of treatments. Other participants, including Dr. Anthony Bozzo, provide insights into the limitations of available data regarding tumor size and its implications for treatment outcomes, reflecting on how socioeconomic factors affect patient care. The panel concludes with logistical considerations for biopsy techniques in highly infiltrative tumors and acknowledges the need for further funding and research to explore advanced imaging strategies.
Overall, the VTT captures a comprehensive exploration of treatment modalities, the interplay between clinical practice and research, and the need for continuous improvement in patient care for those with sarcomas.