Description
In this presentation, Harriet Talbott discusses the morphological changes in the talus due to hemophilia-induced arthritis, notably affecting individuals as young as 20. She outlines her goal of quantifying these changes, highlighting the subjective nature of current classifications. Using an image analysis methodology validated with clinical MRI images, Talbott examines the talar dome, a key area for morphological alterations. She contrasts hemophilia patients with a matched sex-control group to assess disease progression, taking four measurements at three talar locations. The results show significant differences between hemophilia and control groups, indicating nonuniform changes predominantly in the medial talus. Interestingly, the study finds no significant changes in the central talus, with variations unique to each hemophilia patient, influenced primarily by the frequency of joint bleeds. Talbott emphasizes the necessity for quantifiable assessments of these changes linked to disease progression and provides acknowledgments for the clinicians who contributed data.
DOI: 10.1302/3114-221060