Comparison of the Interface Stability of Decellularised Scaffolds to Natural Osteochondral Grafts

Description

This presentation by Marlene Mengoni from Leeds discusses the interface stability of osteochondral grafts, addressing the challenges associated with both allografts and autografts. Marlene highlights the increasing interest in off-the-shelf graft products, emphasizing the importance of assessing their initial stability to prevent subsidence following implantation.



The talk details an experimental approach using a porcine in vitro model, where decellularized products are compared to natural osteochondral grafts in terms of stability. Various tests are performed to measure dislodging forces during graft implantation, revealing that natural grafts require greater force to dislodge than decellularized scaffolds, which are easier to remove. Marlene also discusses the implications of the findings, which suggest that graft density influences interface stability during implantation, although the clinical significance of different stability levels remains uncertain.



Marlene concludes with acknowledgments to Michelle Casper-Taylor for her contributions to the work presented and invites questions from the audience, leading to a brief discussion about the future direction of the research.

DOI: 10.1302/3114-221035

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