Description
This video presents a detailed discussion led by Dr. Brad Rovin regarding current treatment strategies and outcomes for lupus nephritis, with a focus on efficacy of the latest therapies. Dr. Rovin begins by outlining his disclosures and the purpose of the session, which is to review the efficacy of treatments and real-world implications of clinical trials.
Throughout the presentation, Rovin examines the standard of care for lupus nephritis, highlighting clinical trial statistics that show a complete renal response rate of around 35-37% for patients undergoing standard treatments. He notes trends in end-stage kidney disease (ESKD) rates since the 1970s, showing both improvement and recent stagnation, alongside rising mortality rates in lupus nephritis over the last five years.
Dr. Rovin explores various therapies such as mycophenolate, voclosporin, and belimumab, providing data from recent trials like BLISS-LN and analyzing their impact on renal response rates. He notes specific demographics and histological classes most likely to benefit from these treatments, citing the influence of baseline proteinuria levels on treatment effectiveness.
A significant part of the presentation discusses a nuanced approach to treatment initiation based on patient metrics, advocating for early intervention when possible, and stresses the importance of monitoring patient adherence.
As the presentation progresses, Dr. Rovin emphasizes the limitations of complete clinical responses as endpoints, suggesting that residual kidney activity might persist despite apparent clinical improvement. He advocates for re-evaluation through biopsy to understand underlying kidney conditions better.
Overall, Dr. Rovin calls for ongoing discussion and research into lupus nephritis management, emphasizing the need for health professionals to go beyond just reducing protein levels in the urine. He advocates for integrated treatment strategies that look to improve long-term kidney health rather than short-term metrics.
Part of: Surgical Techniques and Training Collection
"Management of Lupus Nephritis " is included in the following Surgical Techniques and Training playlist: