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- Talk
- 13/09/2021
- UK
Mechanical Characterization of Bone Marrow Lesions
Description
In this presentation, Oluwasegun Kayode introduces his research on the mechanical characterization of bone marrow lesions (BMLs) associated with osteoarthritis (OA), a degenerative disease impacting joint health and leading to disability. He highlights that OA predominantly affects individuals over 45, particularly in the knee region, and emphasizes the need for effective treatments to prevent joint replacement procedures.
Kayode explains that BMLs are indicative of bone damage linked to OA progression and can be identified through fat-suppressed MRI scans. His study aims to assess the mechanical properties of the underlying bone in both BML-affected and non-affected regions through experimental and computational methodologies.
Using cadaveric human patellas, he conducted uniaxial compression tests and micro-CT scans to evaluate the bone's elastic properties, discovering differential conversion factors for stiffness that suggest alterations in tissue composition between healthy and BML areas. The results indicated variability in mechanical properties and a lack of correlation between bone volume and modulus in BML regions, implying disrupted structural integrity.
Kayode concludes by acknowledging the support from donors and the EPSRC for funding, followed by a Q&A session where his findings spur further discussion on the nature of BMLs and their implications in trauma versus osteoarthritis contexts.