Description
This webinar discusses the role of dual antibiotic-loaded bone cement in preventing periprosthetic joint infections (PJI). Christof Berberich explains the selective application of this treatment in high-risk infection scenarios rather than routine use. He argues that dual antibiotic combinations in bone cement are more effective than single antibiotics, notably enhancing drug release rates and broadening the spectrum of activity against resistant bacterial strains. Experimental data shows improved antimicrobial action with combinations compared to monotherapies, leading to superior infection control outcomes. Although there is preliminary clinical evidence suggesting lower infection rates with dual antibiotic protocols, recent trials have indicated results that may not achieve statistical significance. The webinar concludes by highlighting the need for further research to confirm the health economic implications of dual antibiotic use in clinical practice.
DOI: 10.1302/3114-240577