Vascularity and Nerve Supply Underpinning Successful Fracture Healing

Description

This talk presented by Chantal Chenu discusses the integration of nerves and blood vessels in bone biology, emphasizing their roles in bone growth, remodeling, and repair. Chenu explains how the interaction between blood supply and nerve function affects bone health, particularly in the context of injury and healing processes. She details the mechanisms of angiogenesis (blood vessel formation) and osteogenesis (bone formation), highlighting the communication between endothelial cells and osteoblasts. The lecture also elaborates on the effects of vasoconstriction and vasodilation on bone repair, the importance of periosteum in providing stem cells for fracture healing, and how mechanical loading influences vascularization and bone remodeling. Chenu emphasizes the significance of nerve innervation in both fracture healing and pain, citing recent studies that reveal how sensory nerves contribute to skeletal repair. She concludes by reflecting on how age-related changes and conditions like diabetes affect bone regeneration and stresses the need for a comprehensive understanding of the signaling pathways connecting nerves, blood vessels, and bone.

DOI: 10.1302/3114-240822

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