Basic Sciences: X-Linked Recessive

Description

In this engaging video lecture from OrthoM8, hosted by Harry Benjamin-Laing, viewers are introduced to the topic of X-linked recessive inheritance. The session begins with an explanation of the genetic makeup of an unaffected father, who possesses a normal X and Y chromosome, and a carrier mother, who has one normal X chromosome and one affected X chromosome. The speaker clarifies that while the mother is not affected, she can pass on the affected allele to her offspring, as the condition is recessive when expressed in a homozygous female.



The video outlines the probabilities associated with their potential offspring, highlighting a 25% chance of producing a normal male or female and a 25% risk of having an affected son or a carrier daughter. The session also hints at common examples of X-linked recessive conditions, inviting the audience to think of them as "easy as ABCD." This informative overview provides a clear understanding of the implications of X-linked recessive inheritance in genetics.

Specialties