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- Talk
- 15/09/2021
- Canada
Characterizing the Effects of Local Intra-Wound Vancomycin Powder on Surgical Site Infection and Bone Healing in a Rat Model
Description
In this presentation, Ikran Ali introduces their research project focusing on the effects of locally applied vancomycin powder on surgical infections and bone healing in a small animal model, particularly involving orthopedic surgeries. Highlighting the incidence and complications caused by surgical-site infections, Ikran details how Staphylococcus aureus is a prevalent pathogen in these contexts, often complicating treatment due to the presence of orthopedic implants. The research aims to explore the efficacy of local antibiotics as a preventive measure against infections while assessing their impact on the healing of fractured bones.
The study employed Mayo spread rats, which were divided into two groups: one contaminated with Staph aureus and the other uncontaminated. Each group received various treatments, including systemic cefazolin, local vancomycin, a combination of both, or no antibiotic at all. The surgical model involved creating a defect in the bones of the rats to observe the outcomes of different antibiotic treatments.
Ikran elaborates on the methods used to evaluate infection and healing through X-rays, microbiological analysis, and Micro-CT scans. Results indicate that while vancomycin effectively prevented infection in contaminated settings, there were no significant differences observed in bone healing when compared to systemic antibiotics alone or in the absence of antibiotics. Ikran concludes that further analysis is necessary, particularly concerning biomechanical testing of fracture healing, and acknowledges the importance of this research in addressing orthopedic surgery complications.