Development of an Ex Vivo Bone Model for Pre-clinically Testing Osseointegration of Metallic Implants

Description

In this presentation, Nupur Kohli explains her initial work on assessing osseointegration for uncemented implants, which rely on a process where surrounding bone interacts with the implant for stability. Nupur describes the importance of osseointegration in ensuring long-term success, detailing the dynamic process involved from the initial damage caused to the bone when drilling, to the subsequent healing phases where various bone cells work together. She discusses current assessment methods, mostly involving animal models, and presents a new preclinical testing method utilizing a unique bioreactor that allows for simulated mechanical stimulation in a sterile environment.



Nupur outlines how they use porcine bone cylinders to study the osseointegration of additively manufactured titanium implants, sharing positive results regarding cell viability within these cylinders and the remodeling processes observed under dynamic conditions. Additionally, she highlights the advantages of this method over traditional animal models, which have limitations. Throughout, Nupur provides insight into her experimental setup, results, and future directions for research, including increasing sample sizes and applying findings to further studies. The discussion also covers comparisons to existing systems and responses to questions from the audience about loading parameters and biological equivalency to human models.

DOI: 10.1302/3114-221045

Specialties

Conferences