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- Talk
- 29/09/2024
- UK
HTA Project NIHR159676: The PORTRAIT Trial - Post-Operative Radiotherapy in Surgically Treated Bone Metastases
Description
This presentation discusses the PORTRAIT trial, aimed at evaluating the effectiveness of post-operative radiotherapy for patients with pathological fractures, particularly those affected by breast and prostate cancer. With a significant number of patients experiencing metastatic bone disease and subsequent pathological fractures, the study seeks to address existing uncertainties regarding the standard practice of administering radiotherapy after surgical intervention.
Mr Jonathan Stevenson's introduction highlights the prevalence of metastatic bone disease and the approach to managing fractures that arise from this condition, emphasizing the importance of surgical intervention for improved patient outcomes. The presentation further critiques the historical reliance on radiotherapy, noting inconsistencies in its efficacy as reported in previous trials.
The trial is designed as a pragmatic randomized comparison, investigating the outcomes of immediate radiotherapy versus deferred treatment following surgery. Mr Stevenson outlines the trial's methodology, including patient recruitment from orthopedic trauma units, and discusses expected outcomes such as pain relief and quality of life improvements. The presentation concludes by acknowledging support from various stakeholders and reiterating the commitment to advancing care for patients suffering from bone metastases.