Rate of Venous Thromboembolism in Patients With Metastatic Bone Disease Requiring Orthopaedic Surgery: A Systematic Review

Description

In this presentation, Daniel You, a third-year orthopaedic surgery resident at the University of Calgary, discusses a systematic review centered on the incidence of venous thromboembolism (VTE) in patients with metastatic bone disease who undergo orthopaedic surgery. He expresses gratitude to the Canadian Orthopaedic Association for the opportunity to present this critical research. Key points include the established connection between active malignancies and major surgery as independent risk factors for VTE, and the variances in guidelines regarding thromboprophylaxis for patients undergoing such procedures. The analysis cites significant data where patients with metastatic bone disease display a higher postoperative VTE rate compared to those undergoing standard arthroplasties, indicating a concerning seven-fold increase in risk. Observations also suggest that pending pathologic fractures carry a notably higher risk for VTE than acute fractures, prompting calls for more tailored thromboprophylaxis regimens. The results underline an urgent need for updated guidelines specific to the demographic of metastatic bone disease patients and emphasize that future research should better define the ideal thromboprophylaxis protocols for this vulnerable patient group.

DOI: 10.1302/3114-220858

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